Children with Acute Hepatitis of Unknown Cause
C. Kelgeri and Others
From January through April 2022, a total of 44 children with acute hepatitis were referred to a liver-transplantation center in the U.K., and 6 underwent liver transplantation; these numbers were higher than those in previous years.Aug 18
S.M. MacDonald and J. Berv
For patients with rare diseases, connecting virtually with specialists across state lines can be the only option for excellent care. So why are state-licensing restrictions being enforced more aggressively than ever?Sep 01
- Original Article Children with Acute Hepatitis of Unknown Cause C. Kelgeri and Others
Telescoping the Diagnostic Process
C.D. Lee and Others
A 3-year-old boy presented with abdominal pain and vomiting. He had associated chills without fever, nonbloody and nonbilious emesis, constipation, reduced urinary output, and a decreased activity level. What is the diagnosis?Sep 01
- Clinical Problem-Solving Telescoping the Diagnostic Process C.D. Lee and Others
Quick Take Once-Weekly Type 2 Diabetes Treatment for Youths
Dulaglutide, a once-weekly injectable GLP-1 receptor agonist, has been available for adults with type 2 diabetes, but more treatment options are needed for children and adolescents. New research findings are summarized in a short video.Aug 4
Most Viewed in Pediatrics
Relative Afferent Pupillary Defect
S. Manjunathan and L. Saini
Current Causes of Death in Children and Adolescents in the United States
J. E. Goldstick, R. M. Cunningham, and P. M. Carter
Effectiveness of BNT162b2 Vaccine against Omicron in Children 5 to 11 Years of Age
S. H.X. Tan and Others
Neuromyelitis Optica Spectrum Disorder
D. M. Wingerchuk and C. F. Lucchinetti
- N Engl J Med 2022; 387:833-838
A 3-year-old boy presented with abdominal pain and vomiting. He had associated chills without fever, nonbloody and nonbilious emesis, constipation, reduced urinary output, and a decreased activity level.
- N Engl J Med 2022; 387:775-777
For patients with rare diseases, connecting virtually with specialists across state lines can be the only option for excellent care. So why are state-licensing restrictions being enforced more aggressively than ever?
- N Engl J Med 2022; 387:e15
A 13-year-old girl with blurry vision, painful eye movements, and weakness and paresthesias in her left leg was found to have a relative afferent pupillary defect in her left eye (shown in a video).
- N Engl J Med 2022; 387:757-759
Canadian data show that legalization of cannabis for adults has been associated with increased hospitalizations for unintentional cannabis poisoning in children, mostly after legalization of cannabis edibles.
- N Engl J Med 2022; 387:587-598
Pregnant women were assigned to be evaluated with lower or higher glycemic criteria for the diagnosis of gestational diabetes. Lower criteria did not reduce the risk of a large-for-gestational-age infant.
- N Engl J Med 2022; 387:656-657
Acute hepatitis in children is certainly not new, and it can be worrisome. Successful worldwide vaccination campaigns over the past few decades have led to demonstrable improvements in public health and well-being by reducing the incidence and consequences of two viral causes — hepatitis A and B viruses. Many other...
- N Engl J Med 2022; 387:611-619
- N Engl J Med 2022; 387:631-639
Formerly known as Devic’s disease, this relapsing, demyelinating disorder of the central nervous system encompasses six syndromes and is associated with aquaporin-4 autoantibodies. Effective treatment prevents relapses.
- N Engl J Med 2022; 387:652-654
In the first decade of this millennium, convincing data showing that screening for and treatment of gestational diabetes mellitus improve both maternal and fetal outcomes1,2 ended debates within the obstetrical community about the usefulness of screening for gestational diabetes. Essentially all U.S. professional societies now recommend universal biochemical...
- N Engl J Med 2022; 387:584-585
For professionals who work with children and adolescents, policies like Florida’s “Don’t Say Gay” law have outsized cruelty — even beyond the enormous harm they will do to the young people we serve.
- N Engl J Med 2022; 387:620-630
A majority of children admitted to a single hospital in late 2021–early 2022 with acute hepatitis of unknown cause tested positive for adenovirus. This report describes the children’s illnesses and outcomes.
- N Engl J Med 2022; 387:488-491
Many children born with sickle-cell disease in sub-Saharan Africa will die before their fifth birthday. Opportunities exist to expand the distribution, use, and oversight of effective medication.
- N Engl J Med 2022; 387:525-532
Data from Singapore on BNT162b2 vaccination in children 5 to 11 years of age showed that during a period of omicron-variant predominance, BNT162b2 reduced the risks of SARS-CoV-2 infection and Covid-19–related hospitalization.
- N Engl J Med 2022; 387:433-443
This trial compared once-weekly dulaglutide, a GLP-1 receptor agonist, with placebo for glycemic control in youths with type 2 diabetes who may have been receiving metformin or basal insulin. Dulaglutide was superior at 26 weeks.
- N Engl J Med 2022; 387:294-297
With policymakers targeting members of sexual and gender minority groups, the health care sector can mitigate resulting harm and advocate for evidence-based policies protecting health and well-being.
- N Engl J Med 2022; 387:237-247
Nine of 10 patients with hemophilia B who received a liver-directed adeno-associated viral vector containing a hyperactive variant of factor IX maintained factor IX activity for up to 42 months. Thrombosis developed in 1 patient.
- N Engl J Med 2022; 387:227-236
Two doses of the BNT162b2 vaccine were associated mainly with low-grade local adverse effects that lasted 2 days or less and afforded nearly 50% protection against omicron infection and symptomatic illness, which was lower than that seen against delta. Greater protection in the youngest group was noted.
- N Engl J Med 2022; 387:109-119
In this study, maternal vaccination with an mRNA vaccine during pregnancy was less common among infants hospitalized for Covid-19 than among controls. The effectiveness of maternal vaccination against Covid-19 hospitalization of infants was 52% overall and was greater when delta, rather than omicron, was predominant.