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Sequential Stem Cell–Kidney Transplantation in Schimke Immuno-osseous Dysplasia

To the Editor: Nearly half the patients with Schimke immuno-osseous dysplasia (SIOD) may have vascular or neurologic problems, including headaches, transient ischemic attacks (TIAs), and cerebral ischemic events. These problems contribute to the morbidity and mortality associated with this condition.1,2 Unfortunately, the underlying pathophysiology of vascular disease in SIOD remains poorly understood.2 We report on the hematopoietic stem-cell transplantation (HSCT) and kidney transplantation from the mother of a 5-year-old patient with SIOD to her child.3 We used the same approach described by Bertaina and colleagues (June 16 issue).4 Details are provided in Table S1 in the Supplementary Appendix, available with . . .

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