Treatment of Diabetic Macular Edema
C.D. Jhaveri and Others
Some insurance companies mandate a form of step therapy, which involves initial use of an inexpensive drug, bevacizumab, to treat diabetic macular edema. This trial compared two treatments: step therapy and use of a more expensive drug.Aug 25
- Original Article Treatment of Diabetic Macular Edema C.D. Jhaveri and Others
Long-Term MC4R Agonist Treatment of POMC Deficiency
P. Kühnen and K. Clément
In this follow-up study involving two patients with POMC deficiency, treatment with the MC4R agonist setmelanotide resulted in a long-term reduction in body weight and BMI and induced satiety.Sep 01
Glycemic Criteria for Diagnosis of Gestational Diabetes
C.A. Crowther and Others
Pregnant women were assigned to be evaluated with lower or higher glycemic criteria for the diagnosis of gestational diabetes. Lower criteria did not reduce the risk of a large-for-gestational-age infant.Aug 18
- Correspondence Long-Term MC4R Agonist Treatment of POMC Deficiency P. Kühnen and K. Clément
Quick Take Once-Weekly Type 2 Diabetes Treatment for Youths
Dulaglutide, a once-weekly injectable GLP-1 receptor agonist, has been available for adults with type 2 diabetes, but more treatment options are needed for children and adolescents. New research findings are summarized in a short video.Aug 4
Most Viewed in Endocrinology
Aflibercept Monotherapy or Bevacizumab First for Diabetic Macular Edema
C. D. Jhaveri and Others
Tirzepatide Once Weekly for the Treatment of Obesity
A. M. Jastreboff and Others
Supplemental Vitamin D and Incident Fractures in Midlife and Older Adults
M. S. LeBoff and Others
Lower versus Higher Glycemic Criteria for Diagnosis of Gestational Diabetes
C. A. Crowther and Others
- N Engl J Med 2022; 387:852-854
- N Engl J Med 2022; 387:692-703
- N Engl J Med 2022; 387:751-752
Step therapy is a treatment approach often required by health insurers to control costs. It involves treating first with a lower-cost medication and, only if that proves ineffective, switching to another, more costly medication. Although step therapy is commonly applied in treating hypertension, diabetes, cancer, and other conditions, concerns regarding...
- N Engl J Med 2022; 387:587-598
Pregnant women were assigned to be evaluated with lower or higher glycemic criteria for the diagnosis of gestational diabetes. Lower criteria did not reduce the risk of a large-for-gestational-age infant.
- N Engl J Med 2022; 387:652-654
In the first decade of this millennium, convincing data showing that screening for and treatment of gestational diabetes mellitus improve both maternal and fetal outcomes1,2 ended debates within the obstetrical community about the usefulness of screening for gestational diabetes. Essentially all U.S. professional societies now recommend universal biochemical...
- N Engl J Med 2022; 387:433-443
This trial compared once-weekly dulaglutide, a GLP-1 receptor agonist, with placebo for glycemic control in youths with type 2 diabetes who may have been receiving metformin or basal insulin. Dulaglutide was superior at 26 weeks.
- N Engl J Med 2022; 387:368-370
An estimated one third or more of U.S. adults 60 years of age or older take vitamin D supplements, not including those who take multivitamins or other compounds containing vitamin D.1 Yet controversy continues about its overall benefits. In this issue of the Journal, LeBoff and...
- N Engl J Med 2022; 387:356-365
A 49-year-old man with a family history of diabetes was evaluated because of hypoglycemia. Two hours earlier, he had been found on the floor, obtunded and making nonpurposeful movements. A diagnostic test was performed.
- N Engl J Med 2022; 387:299-309
A study ancillary to a large trial showed that supplemental vitamin D3 did not lower the risk of fractures among generally healthy midlife and older adults not selected for vitamin D deficiency, low bone mass, or osteoporosis.
- N Engl J Med 2022; 387:205-216
In this randomized trial, adults with obesity treated with weekly tirzepatide, a glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 receptor agonist, had major weight loss over 72 weeks.
- N Engl J Med 2022; 387:271-273
Obesity is a chronic disease affecting millions of people — in 2020, the Centers for Disease Control and Prevention (CDC) reported that the overall prevalence of obesity in the United States during the period from 2017 through 2018 was 42.5%.1 The development of type 2 diabetes is a...
- N Engl J Med 2022; 387:e5
A 78-year-old man with type 2 diabetes presented with hemiballism of the left arm and leg (shown in a video). Evaluation revealed hyperglycemia and an area of increased density in the right basal ganglia on imaging.
- N Engl J Med 2022; 387:261-269
A 34-year-old woman presented with hypercortisolism resulting from a metastatic pancreatic neuroendocrine tumor. Chest CT revealed patchy consolidation with cavitation and tree-in-bud opacities. Management decisions were made.
- N Engl J Med 2022; 386:2316-2326
A 29-year-old woman presented with recurrent bone fractures and hypophosphatemia. The patient had been well until 19 months before admission, when pain in the right foot developed. During the next 19 months, multiple fractures of the metatarsal bones of the right foot occurred. On admission, the blood phosphorus level was...
- N Engl J Med 2022; 386:2161-2164
State efforts to prohibit gender-affirming care place physicians’ duties to avoid discrimination, protect privacy, meet standards of care, fulfill reporting requirements, and avoid committing crimes in direct conflict with one another.
- N Engl J Med 2022; 386:2130-2136
An 85-year-old woman was brought to the emergency department by emergency medical services after losing consciousness. The loss of consciousness occurred approximately 45 minutes after the patient finished eating dinner and was preceded by a sudden onset of sweating, palpitations, and a cold feeling. She had had similar but milder...
- N Engl J Med 2022; 386:e58
A 27-year-old man presented to the dermatology clinic with an asymptomatic rash on his back, arms, and hands that had developed 1 week earlier. Pink-yellow papules were seen on examination. A blood sample was grossly lipemic.