- N Engl J Med 2022; 387:833-838
A 3-year-old boy presented with abdominal pain and vomiting. He had associated chills without fever, nonbloody and nonbilious emesis, constipation, reduced urinary output, and a decreased activity level.
- N Engl J Med 2022; 387:452-458
A 63-year-old woman presented with dyspnea and cough. She had been in her usual state of health until 2 days earlier, when myalgias and dyspnea with ambulation developed, followed by a cough productive of green sputum.
- N Engl J Med 2022; 387:67-73
A previously healthy 18-year-old woman presented to a primary care provider with a 2-month history of headaches and midscapular pain. The midscapular pain was worse at night and lessened with exercise.
- N Engl J Med 2022; 386:2130-2136
An 85-year-old woman was brought to the emergency department by emergency medical services after losing consciousness. The loss of consciousness occurred approximately 45 minutes after the patient finished eating dinner and was preceded by a sudden onset of sweating, palpitations, and a cold feeling. She had had similar but milder...
- N Engl J Med 2022; 386:1742-1749
An 82-year-old woman presented to the emergency department with a 3-week history of severe low back pain, rigors, anorexia, difficulty ambulating, and a sensation of incomplete urination. She had no numbness, tingling, weakness, saddle anesthesia, or fecal incontinence.
- N Engl J Med 2022; 386:880-886
A 17-year-old girl with a history of anxiety and anorexia nervosa presented with anxiety, malaise, lightheadedness, and palpitations. Two weeks earlier, she had entered an intensive outpatient nutritional rehabilitation program. She was found to have hypokalemia, hypophosphatemia, and hypomagnesemia.
- N Engl J Med 2022; 386:479-485
A 61-year-old man was evaluated after having jaundice, light-colored stools, dark urine, pruritus, fatigue, and a temperature of up to 39°C (without chills) for 1 week. He had dull pain in the right upper quadrant of the abdomen and had nausea but no vomiting. Six weeks before jaundice developed, he...
- N Engl J Med 2022; 386:80-87
Confusion developed in a 49-year-old woman with relapsed diffuse large B-cell lymphoma within days after she received CAR-T therapy. She had difficulty putting words together and was disoriented but had no focal abnormalities noted during the neurologic examination.
- N Engl J Med 2021; 385:1797-1802
A 75-year-old man with a history of an untreated hepatitis C virus infection presented with a 4-day history of a pruritic rash on his lower legs. He noted generalized malaise and an unintentional weight loss of 7 kg over the past 2 months. A video showing aortic vegetation is available...
- N Engl J Med 2021; 385:549-554
A 32-year-old woman presented with a 10-year history of intermittent episodes of severe diffuse abdominal pain, occurring every month or two and usually lasting several days, with no apparent precipitant.
- N Engl J Med 2021; 385:66-72
A 67-year-old man presented with a 1-week history of lumbar back pain that worsened with lying down. He had fatigue and had lost 10 kg intentionally over 3 months. He had no fevers, chills, night sweats, weakness or paresthesias in his legs, saddle anesthesia, or incontinence. Additional symptoms arose in...
- N Engl J Med 2021; 384:2145-2152
A 61-year-old man with chronic knee pain was evaluated for elective total knee arthroplasty. During the preoperative visit, his blood pressure was 178/92 mm Hg. On day 1 after surgery, during physical therapy, his blood pressure increased to 216/99 mm Hg, with a heart rate of 141 beats per minute....
- N Engl J Med 2021; 384:1753-1760
A 38-year-old woman who walked several hours per day as a mail carrier had sudden substernal chest pain accompanied by shortness of breath on her way home from work. Emergency coronary angiography and transthoracic echocardiography are shown in videos.
- N Engl J Med 2021; 384:1262-1267
A 22-year-old man presented with progressive neurologic decline. A year before presentation, painless vision loss had occurred in the left eye, followed by the right eye. During the next 4 to 6 months, diffuse numbness, limb stiffness, whole-body weakness, and urinary incontinence had developed.
- N Engl J Med 2021; 384:860-865
A 33-year-old man with a history of smoking and heavy alcohol use presented to the emergency department in September 2019 with fever, vomiting, abdominal pain, and hemoptysis. Two days before admission, malaise, fevers, and chills had developed, followed by diffuse abdominal pain, nausea, and bilious vomiting.
- N Engl J Med 2021; 384:462-467
A 47-year-old man in Michigan presented to the ED with a 1-day history of presyncope, swelling of the eyelids, and diffuse pruritic rash. He reported a 3-week history of postprandial watery bowel movements and a 5-day history of diffuse, crampy abdominal pain.