- N Engl J Med 2022; 387:833-838
A 3-year-old boy presented with abdominal pain and vomiting. He had associated chills without fever, nonbloody and nonbilious emesis, constipation, reduced urinary output, and a decreased activity level.
- N Engl J Med 2022; 387:832-832
A 32-year-old man with daily nitrous oxide inhalant use presented with an inability to walk. MRI of the whole spine revealed hyperintensities in the posterior spinal cord on T2-weighted images.
- N Engl J Med 2022; 387:775-777
For patients with rare diseases, connecting virtually with specialists across state lines can be the only option for excellent care. So why are state-licensing restrictions being enforced more aggressively than ever?
- EditorialAug 27, 202210.1056/NEJMe2209997
Hospitalization for heart failure, usually due to volume overload, is among the most common reasons for hospitalization worldwide, and decongestion with loop diuretics is the primary focus of treatment in most patients.1 Despite the ubiquity of this clinical scenario in daily practice, high-quality data from randomized trials evaluating...
In comatose patients after out-of-hospital cardiac arrest, the incidence of death or severe disability was similar regardless of whether a restrictive or a liberal oxygenation strategy was used.
Among older men in Denmark, the incidence of death from any cause at a median follow-up of 5.6 years was not significantly lower among those randomly invited to undergo screening for subclinical cardiovascular disease.
This trial showed no significant difference in the percentage of patients who died or had severe disability or coma when higher or lower blood-pressure targets were used after an out-of-hospital cardiac arrest.
- EditorialAug 26, 202210.1056/NEJMe2210020
Next year marks the 20th anniversary of the first appearance of the polypill in the medical literature. Wald and Law coined the term to denote a fixed-dose combination of medications for preventing cardiovascular disease.1 They suggested that administering a polypill to all adults 55 years of age or...
- Original ArticleAug 26, 202210.1056/NEJMoa2208275
Among patients with recent MI, therapy with a polypill containing aspirin, ramipril, and atorvastatin led to a lower incidence of major adverse cardiovascular events at a median of 3 years than usual care.
- N Engl J Med 2022; 387:e15
A 13-year-old girl with blurry vision, painful eye movements, and weakness and paresthesias in her left leg was found to have a relative afferent pupillary defect in her left eye (shown in a video).
- N Engl J Med 2022; 387:737-737
A 61-year-old woman with primary biliary cholangitis and Raynaud’s phenomenon was referred to the rheumatology clinic. Tongue telangiectasias, puffy fingers, and nailfold capillary hemorrhage were present.
- N Engl J Med 2022; 387:738-747
A 48-year-old woman was evaluated for abdominal pain. CT showed numerous liver lesions and lung cysts and nodules; liver biopsy revealed an eosinophilic inflammatory infiltrate. A diagnosis was made.
- N Engl J Med 2022; 387:672-675
For the one in nine hospitalized U.S. adults who have SUD, hospital-based addiction care has critical health benefits. But most hospitals don’t offer such care.
- N Engl J Med 2022; 387:640-640
An 86-year-old woman presented with acute pain on the right side of her abdomen. Computed tomography revealed a distended gallbladder outside the gallbladder fossa and swirling of the cystic artery and duct.
- N Engl J Med 2022; 387:641-650
A 25-year-old woman was evaluated for worsening headaches, photophobia, nausea, vomiting, and blurred vision. MRI revealed hydrocephalus and leptomeningeal enhancement. CSF analysis revealed neutrophilic pleocytosis.
- N Engl J Med 2022; 387:577-579
Health worker burnout, exacerbated by Covid-19, is not only about long hours. It’s about the fundamental disconnect between health workers and the mission to serve that motivates them.
- N Engl J Med 2022; 387:e14
A 74-year-old woman with psoriatic arthritis presented with swelling of the fifth finger. On examination, there were nontender, subcutaneous nodules in the hypothenar region and over the fifth finger.