- N Engl J Med 2022; 387:833-838
A 3-year-old boy presented with abdominal pain and vomiting. He had associated chills without fever, nonbloody and nonbilious emesis, constipation, reduced urinary output, and a decreased activity level.
- N Engl J Med 2022; 387:832-832
A 32-year-old man with daily nitrous oxide inhalant use presented with an inability to walk. MRI of the whole spine revealed hyperintensities in the posterior spinal cord on T2-weighted images.
- N Engl J Med 2022; 387:e15
A 13-year-old girl with blurry vision, painful eye movements, and weakness and paresthesias in her left leg was found to have a relative afferent pupillary defect in her left eye (shown in a video).
- N Engl J Med 2022; 387:737-737
A 61-year-old woman with primary biliary cholangitis and Raynaud’s phenomenon was referred to the rheumatology clinic. Tongue telangiectasias, puffy fingers, and nailfold capillary hemorrhage were present.
- N Engl J Med 2022; 387:738-747
A 48-year-old woman was evaluated for abdominal pain. CT showed numerous liver lesions and lung cysts and nodules; liver biopsy revealed an eosinophilic inflammatory infiltrate. A diagnosis was made.
- N Engl J Med 2022; 387:640-640
An 86-year-old woman presented with acute pain on the right side of her abdomen. Computed tomography revealed a distended gallbladder outside the gallbladder fossa and swirling of the cystic artery and duct.
- N Engl J Med 2022; 387:641-650
A 25-year-old woman was evaluated for worsening headaches, photophobia, nausea, vomiting, and blurred vision. MRI revealed hydrocephalus and leptomeningeal enhancement. CSF analysis revealed neutrophilic pleocytosis.
- N Engl J Med 2022; 387:e14
A 74-year-old woman with psoriatic arthritis presented with swelling of the fifth finger. On examination, there were nontender, subcutaneous nodules in the hypothenar region and over the fifth finger.
- N Engl J Med 2022; 387:e12
A 51-year-old man with chronic myeloid leukemia who was receiving treatment with nilotinib presented for follow-up with a report that his hair had turned from gray to its original brown color.
- N Engl J Med 2022; 387:547-556
A 31-year-old man was admitted with perianal and penile ulcers, rectal pain, and vesiculopustular rash. He had first noticed itchy white “bumps” around the anus 9 days earlier. A diagnostic test was performed.
- N Engl J Med 2022; 387:e9
This interactive feature describes a 50-year-old woman who presents to the ED with progressive neurologic symptoms and is admitted to the neurology service. Test your diagnostic and therapeutic skills at NEJM.org.
- N Engl J Med 2022; 387:451-451
A 68-year-old woman living in Japan presented with a 5-day history of rash and fevers. She had been bitten by a tick 1 week earlier. Examination revealed a petechial rash and eschar on the ankle.
- N Engl J Med 2022; 387:e8
A 47-year-old woman presented with shortness of breath. Chest CT showed a filling defect in the left atrium, and a mobile left atrial mass was seen on transthoracic echocardiography (shown in a video).
- N Engl J Med 2022; 387:452-458
A 63-year-old woman presented with dyspnea and cough. She had been in her usual state of health until 2 days earlier, when myalgias and dyspnea with ambulation developed, followed by a cough productive of green sputum.
- N Engl J Med 2022; 387:356-365
A 49-year-old man with a family history of diabetes was evaluated because of hypoglycemia. Two hours earlier, he had been found on the floor, obtunded and making nonpurposeful movements. A diagnostic test was performed.
- N Engl J Med 2022; 387:355-355
A 59-year-old woman with a history of smoking tobacco presented with a 5-month history of darkening of the skin on her palms. Velvety thickening on the palms and fingers was observed on physical examination.
- N Engl J Med 2022; 387:e7
A 23-year-old man presented with double vision and eyelid drooping on the right side that worsened at the end of the day. The neurologic examination showed ptosis on the right side and “curtain sign” (as seen in a video).
- N Engl J Med 2022; 387:260-260
A 26-year-old woman presented with sore throat, pain while swallowing, shortness of breath, and fever. Marked swelling of the posterior oropharynx was observed on physical examination, and CT of the neck was performed.